By Gilles Grateau, Robert A. Kyle, Martha Skinner
This authoritative quantity includes 179 chapters through overseas specialists on contemporary advancements in our realizing of amyloid proteins, protein folding issues, and new and proposed medical trials in amyloidosis. subject matters contain detection and characterization recommendations; organic capabilities; genetics; issues, analysis, and coverings, together with organ transplants and drug remedies; effects from wide medical experiences; and epidemiology. it is a beneficial source for clinicians who deal with sufferers with systemic and localized sorts of amyloidosis, and for researchers in biochemistry, neurobiology, and cellphone biology.
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Extra info for Amyloid and amyloidosis
AMYLOIDOSIS IN VIVO: FROM MOLECULAR INTERACTIONS TO THERAPEUTIC TARGETS R. Kisilevsky Department of Pathology and Molecular Medicine, Queen’s University, and The Syl and Molly Apps Research Centre, Kingston General Hospital, Kingston Ontario CANADA, K7L 3N6 INTRODUCTION Over the last 15-20 years, based on in vitro studies, major progress has been made in understanding the mechanism of amyloid fibrillogenesis. These studies revealed that proteins with amylodogenic potential exist in a native conformation in equilibrium with forms that possess intermediate conformations.
Heinz Fabian, Fabian Sokolowski, Gudrun Lutsch, Klaus Gast, and Gregor Damaschun. “Polymerization of proteins into amyloid protofibrils shares common critical oligomeric states but differs in the mechanisms of their formation”. To appear in Amyloid – The Journal of Protein Folding Disorders (2004). STATUS OF CONGO RED STAINED AMYLOID IN POLARIZED LIGHT Bart Kahr, Werner Kaminksy, Kacey Claborn, Miki Kurimoto, Lee-Way Jin Departments of Chemistry and Pathology, University of Washington, Seattle WA 98195 New advances in polarized light microscopy have been employed to image Congo red (CR) stained amyloid 1 plaques in sharp relief.
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Amyloid and amyloidosis by Gilles Grateau, Robert A. Kyle, Martha Skinner
Categories: Basic Science